Recently I learned that Matt Mercer (of 'Critical Role' fame) has body dysmorphia. That blew my mind, because by anybody's standards, he's extremely handsome. I'm not saying your wife has that, because it's specific, but feelings of that kind have nothing to do with outside attractiveness. I hope your wife can learn some strategies to cope with it. Matt Mercer has been fighting it for 15 years and still struggles.