CytoLinX® BR Single-Use Bioreactors come standard with working volumes of 10L, 50 L, 200 L, 500 L, 1000 L, and 2000L. Including a vessel, a controller and a temperature control unit (TCU), they are used for culturing mammalian cells, insect cells, and other low shear-rate needed cells.
More About CytoLinX® BR 10-2000L Single-use Bioreactor
CytoLinX® BR 10-2000L single use stirred tank bioreactor is developed based on DCS architecture, and its underlying logic is built by Siemens PCS 7, so as to cover the automatic control requirements from R&D to production, from a single unit to the whole upstream plant, and its automatic control logic conforms to ISA 88 control standards. The disposable bioreactor for cell culture can cover10, 50, 200, 500, 1000, 2000 L scale, its software design in accordance with GMP and 21 CFR Part 11 requirements. At the same time, in order to facilitate the use of users, CytoLinX® BR 50 2000 l bioreactor is minimal, all functions at a glance, and can greatly meet the needs of customers. The automatic control system can meet the functions of real-time data acquisition and recording, PID automatic control, online monitoring, multi-parameter cascade control, and has stable pH, DO, temperature control performance.
For more efficient mixing, BioLink has introduced a new bottom dial design that can maintain a high linear KLa. And provide microbubble, medium bubble, large bubble and a variety of combinations of consumable solutions, to meet the needs of a variety of cells tricky culture.
The supporting single-use consumables can be selected according to the needs of customers, such as micro-bubble, medium-bubble, big-bubble and other ventilation combinations. The perfusion bioreactor has a stable linear KLa, and the cultivation effect is comparable to most reactors on the market.
Functions of CytoLinX® BR 50-2000L Single-use Bioreactor
CytoLinX® BR 10-2000L Single-use Bioreactor comes standard with working volumes of 10L，50 L, 200 L, 500 L, 1000 L, and 2000 L. Including a vessel, a controller and a temperature control unit (TCU), it is used for culturing mammalian cells, insect cells, and other low shear-rate needed cells.
CytoLinX® BR Controller — The Controller of Single-use Bioreactor
CytoLinX® BR controller consists of control hardware and underlying hardware modules. The 10 L model uses the same controller as the glass bioreactor, while the 50-2000 L models are built on the PCS 7 architecture, meeting the automation requirements from research to production, as well as from single system to enterprise-wide solution. The software fits ISA 88 control standard and 21 CFR Part 11.
Hardware control units are all built with international famous brands to ensure robust and reliable performance. Also, a choice of PAT tools can be configured flexibly to meet different customer needs and applications.
One CytoLinX® BR 50-2000 L controller can control different types of BioLink Single-use bioreactor vessels at the same time. We can also use CytoLinX® BR controller as an integrated control center to realize upstream centralized control by controlling several Single-use bioreactors vessels simultaneously.
CytoLinX® BR Vessel — The Vessel of Single-use Bioreactor
CytoLinX® BR Vessel operates with bottom-drive agitators. It has a patented sparge design that supports flexible combinations of micro, medium and macro sparge sizes, helping to optimize the culture process, enhance the cell density, and maintain cell viability.
For the operation of CytoLinX® BR, two types (air-cooled and water-cooled) of temperature control units (TCU) are available to meet customers' specific needs in different applications.
Features of CytoLinX® BR 10-2000L Single-use Bioreactor
A single controller supports the control of multiple vessels by plugging and unplugging, which contributes to significant cost reduction;
50-2000 L Reliable PCS 7 system that meets ISA 88 standard, applicable for whole-plant control;
The software is designed with user-friendly interface in compliance with 21 CFR Part 11;
Flexible configurations, partly customizable upon customer requirements;
The main parts are all high-end brands and passed the inspection before leaving the factory to ensure normal operation;
The sparge provides micro, medium, and macro sparge size options to meet various processing needs;
Complete FAT, SAT, and IQOQ documents/services are available;
Rich application and operation support, and high-speed response speed.
CytoLinX® MBR 50 L Single-use Microbial Bioreactor
CytoLinX® MBR 50 L Microbial Bioreactor is a fermenter system specially designed for microbial culture. It consists of a vessel, a controller, and a temperature control unit (TCU). With disposable matching consumables, this Microbial Bioreactor is a cost-effective industrial tool with no risk of cross-contamination. It is easy to operate with minimal water consumption and short batch-to-batch turnover time. The Bioreactors can be used for both microbial culture and cell culture. The culture of CHO cells, Vero cells, and MDCK cells is supported.
CytoLinX® MBR Controller ﹣ The Controller of Single-use Microbial Bioreactor
CLX-MBR controller consists of control hardware and underlying hardware modules. CLX-MBR's controller is built with the control hardware of SIEMENS PCS 7 which meets the automation requirements from research to production, as well as from single system to enterprise-wide solution. The software fits ISA 88 control standard and 21 CFR Part 11 requirements. Hardware control units are all built with international famous brands to ensure robust and reliable performance. Also, a choice of PAT tools can be configured flexibly to meet different customer needs and applications.
CytoLinX® MBR Vessel ﹣ The Vessel of Single-use Microbial Bioreactor
CLX-MBR vessel operates with bottom-driven agitators. It has a patented sparge design that supports flexible combinations of micro, medium and macro sparge sizes, helping to optimize the culture process and increase the yield. The vessel is designed with 3 removable vortex plates, 1 degassing condenser, and 2 vent filter heating jackets. The vortex plates can enhance mixing for better mixing results. The degassing condenser returns the water that may be entrained in the vent gas due to the rapid gas flow. P
Product Features
A single controller supports the control of multiple vessels by plugging and unplugging, which contributes to significant cost reduction • Reliable PCS 7 system that meets ISA 88 standard, applicable for whole-plant control • User-friendly interface in compliance with 21 CFR Part 11 • Powerful magnetic bottom-driven device for effective mixing to realize a uniform mixing result • Two-stage impellers for high oxygen transfer speed • Micro, medium, and macro sparge size options for various processing needs • Dimple jackets for heat transfer to support efficient cooling and heating • Flexible configurations, partly customizable upon customer requirements
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