I typically take 1/2 gram, 25% white and 75% green maeng da.
As soon as I wrote it’s peaky and my fatigue is below baseline if I’m not currently on it, but have been using it recently, this suddenly seems to not be the case. My fatigue levels are improving now, and it’s been a few days since I’ve done any. I’m only doing it a few times a week.
It’s been a bit warmer lately, so it’s entirely possible I mis-attributed fatigue from the temperature or some other factor. I seem to have random fatigue episodes, anyway, and I cannot find a solid cause. Hence why I’m blaming it on random things like drugs and weather.
That said, if one sticks to less than a gram, and don’t have any contraindications going on, I’m fairly confident dependence will be slow/difficult to build and withdraw will be tolerable. (this is a report, not medical advice, your mileage may vary, etc)
Beware of combing with other central nervous system depressants, in particular: alcohol, other opiates, benzos, most things that make you sleepy. This is how 80% of deaths with kratom in one’s system occur.
Also, even at low doses it causes nausea fairly easily. To avoid, take on an empty stomach. I wait 2 hours after eating. Some meals like pork seem to require more space. Ginger candies & cannabis are also helpful here.
As for the effects: I don’t experience chronic pain, and have found OTC medications mostly adequate for my random-ass headaches. I find it helpful to focus on some things. It’s not equally helpful at all tasks. It’s better at “starting” the task than finishing it, if you get my meaning. It’s a sort of energetic, impulsive feeling, especially white, which is why I use less of that.
Green is the most well-rounded vein, in my opinion. I have enjoyed reds as well, but I don’t keep buying them.
My mix does induce a ‘buzz’, without a close comparison. It feels more like stimulants than caffeine, but really doesn’t feel like either. Overall, I think it’s just a nice anti-depressant and mood uplift, not dramatic.
I have tried large doses, a gram or two, aiming for euphoria, and I did get a body high out of it. But that makes my stomach upset and it’s not really worth it. Just get some weed and mushrooms, instead.
The Kratom leaf is a psychoactive, traditionally chewed to provide euphoria. Its leaves contain 7-Hydroxymitragynine and mitragynine which act as a μ-opioid receptor partial agonist like morphine, and can be used to treat chronic pain. The leaves are chewed as an opioid substitute and stimulant in Thailand and especially in the southern peninsula. Kratom is also used primarily among the working class in neighboring countries in Southeast Asia where it grows naturally.
Mitragynine has traditionally been cited as the primary active chemical in kratom leaves, but some recent evidence points to 7-hydroxymitragynine instead. The pharmacological effects of kratom on humans are not well studied.
Mitragyna speciosa is a tropical evergreen tree native to Southeast Asia. It is indigenous to Cambodia, Thailand, Indonesia, Malaysia, Myanmar, and Papua New Guinea, where its dark green, glossy leaves, known as kratom, have been used in herbal medicine since at least the 19th century.
Anecdotal reports describe increased alertness, physical energy, talkativeness, sociability, sedation, changes in mood, and pain relief
In Thailand, kratom was “used as a snack to receive guests and was part of the ritual worship of ancestors and gods”. The herb is bitter and is generally combined with a sweetener.
Side effects run the gamut of what is common for opiates. I have not any comparison to another opiate but I’m guessing far milder than most.
Common side effects include appetite loss, erectile dysfunction, nausea and constipation.
More severe side-effects may include respiratory depression (decreased breathing), seizure, psychosis, elevated heart rate and blood pressure, trouble sleeping, and liver injury. Addiction is a possible risk with regular use: when use is stopped, withdrawal symptoms may occur. Serious toxicity is rare and generally occurs at high doses or when kratom is used with other substances.
Kratom products in the U.S. are commonly used in doses of 2–6 g of dried leaf, and doses exceeding 8 g are uncommon. Given that kratom products may vary greatly in potency, there is no standard dosing system.
At relatively low doses (1–5 g of raw leaves), at which there are mostly stimulant effects, side effects include contracted pupils and blushing; adverse effects related to stimulation include anxiety and agitation, and opioid-related effects such as itching, nausea, loss of appetite, and increased urination begin to appear.
At moderate to high doses (5–15 g of raw leaves), at which opioid effects generally appear, additional adverse effects include tachycardia (an increased stimulant effect) as well as the opioid side effects of constipation, dizziness, hypotension, dry mouth, and sweating.
In the US, kratom is available in outlets such as head shops and over the Internet.
wikipedia: mitragyna speciosa
Pharmaceutical profile of Kratom Kratom (Mitragynine, 7-Hydroxy-Mitragynine, Speciogynine, Paynantheine, Speciociliatine, Corynantheidine, Corynoxeine, Corynoxine B, Speciofoline)
- Onset: 30 minutes
- Peak plasma time: 1-4.5 hrs
- Duration: 3 or more hours
- Half-life: 12–45 hours
Receptors:
- Kappa: competitive antagonist
- Delta: competitive antagonist
- Mu: partial agonist
- α2 adrenergic
- Adenosine A2a
- Dopamine D2
- Serotonin receptors 5-HT2C and 5-HT7
Mechanism of action: Competitive antagonist at Kappa opioid receptors with stronger affinity compared to other receptors, competitive antagonist at Delta opioid receptors. Partial agonist at Mu opioid receptors. Causes G-protein linked second messenger activation, and calcium channel blocker.
Metabolism: Cytochrome P-450, inhibitor of CYP2D6 and CYP3A
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