Increasing demands on protein product quality lead to greater complexity of production process and analysis, therefore, require development and optimization of the production process. With the state-of-the-art technology and years of experiences in protein production, Creative Biostructure now provides custom process development and manufacturing services for recombinant soluble/membrane protein expression and purification. Our services emphasize on developing the optimal “from gene to protein” process for each individual case to meet your special requirements and objective in academic or industrial applications.
Upstream process development

Protein and gene analysis. All information about the target protein can be helpful for the choosing of expression and purification techniques. We will take a comprehensive consideration of all the critical properties to help develop the optimal strategies, including but not limited to molecular size, isoelectric point, temperature stability, ionic strength stability, detergent requirement, biospecific affinity, etc.
Protein recombination and expression. Specific affinity tag, vector, and expression system will be determined based on gene variety and requirements of future protein products. We provide histine-, MBP-, GST-, Strep-tag II-and other kinds of tagged recombinant protein vector construction, and various expression systems including bacteria, yeast, insect cells, plant cells, and mammalian for different applications.